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Explore the Johns Hopkins Lung Project
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The Johns Hopkins Lung Project was a two-arm randomly assigned study designed to determine whether the addition of cytologic screening to the radiographic screening of at-risk volunteers (Male smokers 45 or older) could enhance the early detection of asymptomatic lung cancer and whether early therapeutic intervention in detected cases could significantly reduce the mortality from this disease.

Study Years: 1974-1984

Randomized trial with two arms:

  • Arms
    • Arm I: Control: X-ray Only (Only annual PA and lateral chest roentgenograms)
    • Arm II: Screening: Dual-screen (Similar roentgenographic examinations as well as sputum cytology examinations every 4 months)

Study Eligibility:
  • Ages Eligible for Study: 45 or older
  • Sexes Eligible for Study: Male
  • Smoked at least 1 pack of cigarettes per day (or who had smoked this much within one year of enrollment)
  • No prior history of respiratory tract cancer
  • From the Baltimore metropolitan area