Association of dietary fat intake and sedentary time with ovarian cancer risk
Principal Investigator
Name
Bingyan Li
Degrees
M.D.
Institution
Soochow University
Position Title
Professor, Doctoral Supervisor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1726
Initial CDAS Request Approval
Nov 5, 2024
Title
Association of dietary fat intake and sedentary time with ovarian cancer risk
Summary
Ovarian cancer remains one of the most lethal gynecological malignancies, and understanding its risk factors is critical for prevention and early intervention. Previous research indicates that lifestyle factors such as diet, and physical activity may influence cancer risk. High intake of saturated and trans fats has been linked to various cancers, but its specific role in ovarian cancer warrants further exploration. Additionally, sedentary behavior is increasingly recognized as a risk factor for several chronic diseases, including cancer. Regardless of physical activity, prolonged sitting is independently associated with harmful health outcomes, including cancerous, metabolic and cardiovascular disease. However, the impact of sedentary behavior on the incidence of ovarian cancer and on mortality remains unknown.
We conducted a cohort study on ovarian cancer in China to assess the association between different types of dietary fats and ovarian cancer incidence. As well as to assess the effect of sedentary behaviors (e.g. sedentary and low exercise) on ovarian cancer risk. However, our study may be relatively small in population size, and the current conclusions may be affected by a variety of factors such as ethnicity, lifestyle, and dietary patterns of the study population. There may be limitations in extrapolating the findings to the whole population. Therefore, we were eager to analyse the data from PLCO and SQX, and to compare them with our findings.The results of this study are expected to provide a scientific basis for the prevention of ovarian cancer and provide rational dietary and lifestyle recommendations for disease management.
We conducted a cohort study on ovarian cancer in China to assess the association between different types of dietary fats and ovarian cancer incidence. As well as to assess the effect of sedentary behaviors (e.g. sedentary and low exercise) on ovarian cancer risk. However, our study may be relatively small in population size, and the current conclusions may be affected by a variety of factors such as ethnicity, lifestyle, and dietary patterns of the study population. There may be limitations in extrapolating the findings to the whole population. Therefore, we were eager to analyse the data from PLCO and SQX, and to compare them with our findings.The results of this study are expected to provide a scientific basis for the prevention of ovarian cancer and provide rational dietary and lifestyle recommendations for disease management.
Aims
Primary objective:
1. To assess the relationship between different types of dietary fat (saturated fat, unsaturated fat, trans fat, etc.) and the risk of ovarian cancer.
2. To assess the impact of sedentary behaviors (e.g. sedentary and low physical activity) on the risk of ovarian cancer and patient prognosis.
Secondary Objectives:
1. To assess the impact of anxiety and depression on disease progression in patients with ovarian cancer.
Collaborators
ovarian cancer,
dietary fat,
sedentary behaviors