Association Between Protein Diet Score And Colorectal Adenoma Risk: A Prospective Study
Principal Investigator
Name
Haitao Gu
Degrees
M.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1724
Initial CDAS Request Approval
Nov 5, 2024
Title
Association Between Protein Diet Score And Colorectal Adenoma Risk: A Prospective Study
Summary
Colorectal cancer (CRC) is the third most common cancer worldwide(1). Most CRC develops through the adenoma-carcinoma sequence, leading developed countries to implement screening programs for colorectal adenomas that have effectively reduced CRC incidence and mortality(2). Beyond screening, identifying modifiable risk factors, particularly dietary factors, is crucial for primary prevention.
Studies have shown that various nutrients influence colorectal adenoma risk. While protein's role in intestinal health has been suggested, evidence linking protein intake to colorectal adenoma risk remains limited(3). Additionally, recent dietary guidelines emphasize increasing plant-based protein consumption, as proteins from different sources may affect intestinal health differently(4).
To investigate this relationship between protein and colorectal adenoma, we analyzed data from the PLCO Screening Trial, using the Protein Diet Score to comprehensively evaluate both the quantity and quality of protein intake.
References
1. Siegel R L, Giaquinto A N, and Jemal A. Cancer statistics, 2024. CA Cancer J Clin. (2024) 74:1. doi:10.3322/caac.21820
2. Winawer S J, Zauber A G, Ho M N, O'Brien M J, Gottlieb L S, Sternberg S S, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. The New England journal of medicine. (1993) 329:27. doi:10.1056/nejm199312303292701,Brenner H, Hoffmeister M, Stegmaier C, Brenner G, Altenhofen L, and Haug U. Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies. Gut. (2007) 56:11. doi:10.1136/gut.2007.122739
3. Yang S Y, Kim Y S, Lee J E, Seol J, Song J H, Chung G E, et al. Dietary protein and fat intake in relation to risk of colorectal adenoma in Korean. Medicine. (2016) 95:49. doi:10.1097/md.0000000000005453
4. Willett W, Rockström J, Loken B, Springmann M, Lang T, Vermeulen S, et al. Food in the Anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems. Lancet (London, England). (2019) 393:10170. doi:10.1016/s0140-6736(18)31788-4
Studies have shown that various nutrients influence colorectal adenoma risk. While protein's role in intestinal health has been suggested, evidence linking protein intake to colorectal adenoma risk remains limited(3). Additionally, recent dietary guidelines emphasize increasing plant-based protein consumption, as proteins from different sources may affect intestinal health differently(4).
To investigate this relationship between protein and colorectal adenoma, we analyzed data from the PLCO Screening Trial, using the Protein Diet Score to comprehensively evaluate both the quantity and quality of protein intake.
References
1. Siegel R L, Giaquinto A N, and Jemal A. Cancer statistics, 2024. CA Cancer J Clin. (2024) 74:1. doi:10.3322/caac.21820
2. Winawer S J, Zauber A G, Ho M N, O'Brien M J, Gottlieb L S, Sternberg S S, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. The New England journal of medicine. (1993) 329:27. doi:10.1056/nejm199312303292701,Brenner H, Hoffmeister M, Stegmaier C, Brenner G, Altenhofen L, and Haug U. Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies. Gut. (2007) 56:11. doi:10.1136/gut.2007.122739
3. Yang S Y, Kim Y S, Lee J E, Seol J, Song J H, Chung G E, et al. Dietary protein and fat intake in relation to risk of colorectal adenoma in Korean. Medicine. (2016) 95:49. doi:10.1097/md.0000000000005453
4. Willett W, Rockström J, Loken B, Springmann M, Lang T, Vermeulen S, et al. Food in the Anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems. Lancet (London, England). (2019) 393:10170. doi:10.1016/s0140-6736(18)31788-4
Aims
To investigate the association between Protein Diet Score and colorectal adenoma risk
Collaborators
Yangpiaoyi Shi, Wanhao Tan, Yi Xiao, Zhiquan Xu, Linglong Peng, Ling Xiang, Haitao Gu et al.
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China