Metabolites related to gut microbiota, polygenic risk score and cancer Risk
Principal Investigator
Name
Fangfang Song
Degrees
Ph.D.
Institution
Tianjin Medical University Cancer Institute and Hospital
Position Title
Associate professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1590
Initial CDAS Request Approval
Jun 7, 2024
Title
Metabolites related to gut microbiota, polygenic risk score and cancer Risk
Summary
Gut microbiota is an important factor affecting cancer. When the gut microbiota is unbalanced, it can promote the occurrence and progression of cancer by regulating the host inflammatory response, inhibiting the function of immune cells, mediating the damage of deoxyribonucleic acid (DNA), etc., and can also show a variety of cancer-promoting and anticancer effects on cancer through metabolites related to gut microbiota. In addition, it is well known that genetic factors play a role in determining a risk of developing cancer. The evidence has shown that the polygenic risk score (PRS) can effectively measure the genetic susceptibility to cancer. However, there is still a lack of comprehensive and systematic epidemiological studies on associations between metabolites related to gut microbiota and cancer risk, as well as the combined influence of metabolites related to gut microbiota and genetic risk on cancer risk.
Aims
The primary purpose of this study is to investigate associations between metabolites related to gut microbiota and cancer risk, then examined the combined influence of metabolites related to gut microbiota and genetic risk on cancer risk based on data from PLCO, UK Biobank and Tianjin Medical University Cancer Institute and Hospital.
Collaborators
No collaborators