Interactions, mediating effects, and nonlinear effects of biological markers, genomics and environmental exposures on the occurrence and prognosis of various types of cancers
Principal Investigator
Name
Jiahui Lao
Degrees
M.D.
Institution
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University
Position Title
Mr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1550
Initial CDAS Request Approval
May 14, 2024
Title
Interactions, mediating effects, and nonlinear effects of biological markers, genomics and environmental exposures on the occurrence and prognosis of various types of cancers
Summary
Although numerous studies have explored the influencing factors of the occurrence and prognosis of cancer, the interactions, mediating effects, and nonlinear effects of these factors has not been thoroughly explored. Therefore, this proposal aims to explore the impacts, especially interactions, mediating effects, and nonlinear effects, of biological markers, genomics and external environmental exposures (lifestyle, diet, etc.) on the occurrence and prognosis of various types of cancer, based on the cohort established from the PLCO trial. To achieve this goal, we look forward to collecting information of questionnaire, screening, laboratory testing, GWAS, etc. The additive and multiplicative interactions between influencing factors will be explored. Generalized additive models and restricted cubic spline functions will be used to examine nonlinear relationships. We will also explore how genotype and environmental exposures influence the occurrence and prognosis of cancer through biomarkers, by path analysis.
Aims
This proposal aims to explore the interactions, mediating effects, and nonlinear effects, of biological markers, genomics and environmental exposures on the occurrence and prognosis of various types of cancer.
Collaborators
Qijun Wu, Department of Clinical Epidemiology, Shengjing Hospital of China Medical University
Tingting Gong, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University
Lang Wu, Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa
ChunQing Lin, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College