Lifu Lei

M.D.

The Second Affiliated Hospital of Chongqing Medical University

Registered Dietitian

PLCO (Learn more about this study)

PLCO-1491

Mar 11, 2024

Association between adherence to Eat-Lancet diet and incidence and mortality of liver cancer: A prospective cohort study

Primary liver cancer is one of the seven most common cancers and the second leading cause of cancer deaths globally. In 2020, there were approximately 905,677 new cases of liver cancer diagnosed and an estimated 830,180 deaths due to liver cancer. The specific mechanisms behind liver cancer remain unclear, but dietary habits have been considered to play a moderate role. Indeed, numerous epidemiological studies have showed that there were significant associations between dietary behaviors and the risk of liver cancer. Eat-Lancet diet (ELD) as a specific sustainable dietary pattern recommended for promoting environmental sustainability and reducing chronic disease incidence and mortality associated with diet. To our knowledge, few previous studies have investigated the association of ELD with incidence of cancer, and they have concluded that adherence to the ELD could decrease the risk of cancer only in some subgroups or specific cancers (e.g., colorectal cancer, lung cancer). However, no studies have explored the association between ELD and the incidence and mortality of of liver cancer. To address these knowledge gaps, we conducted this study to explore the potential association of adherence to ELD with the incidence and mortality of liver cancer and its subtypes in a large US population from the the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort.