The association between Energy-adjusted Dietary Inflammatory Index (E-DII) and lung cancer: a large prospective cohort
Principal Investigator
Name
Haitao Gu
Degrees
M.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1442
Initial CDAS Request Approval
Jan 9, 2024
Title
The association between Energy-adjusted Dietary Inflammatory Index (E-DII) and lung cancer: a large prospective cohort
Summary
Despite a continuous decline since 2006, lung cancer is projected to maintain its position as the world's second highest in incidence, making it a significant global public health concern [1, 2]. While smoking and family history of lung cancer are recognized as risk factors, other factors such as chronic inflammation also contribute to the development of lung cancer[3]. Considerable evidence underscores the pivotal roles of inflammation and inflammation-induced immune responses in the occurrence and progression of lung cancer[4]. Inflammation characterized by immune cell infiltration and the release of various mediators[5], such as cytokines and chemokines, can foster tumor growth and spread through several mechanisms, including the generation of nitric oxide and oxygen radicals[6], leading to oxidative stress[7], and the formation of the tumor microenvironment (TME) [8] . The DII is a scoring system derived from the weighted calculation of dietary intake levels associated with six inflammatory biomarkers (IL-1β, IL-4, IL-6, IL-10, TNF-α, and CRP)[9]. It serves as a food assessment tool linked to inflammation, characterizing the inflammatory features of dietary. However, previous research findings on the association between DII and lung cancer incidence have been inconsistent[10-12]. Thus, we conducted this study using prospective data from the PLCO trial.
1. Siegel, R.L., et al., Cancer statistics, 2023. CA Cancer J Clin, 2023. 73(1): p. 17-48.
2. Islami, F., et al., Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin, 2018. 68(1): p. 31-54.
3. Bade, B.C. and C.S. Dela Cruz, Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med, 2020. 41(1): p. 1-24.
4. Grivennikov, S.I., F.R. Greten, and M. Karin, Immunity, inflammation, and cancer. Cell, 2010. 140(6): p. 883-99.
5. Kidane, D., et al., Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol, 2014. 49(2): p. 116-39.
6. Maeda, H. and T. Akaike, Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc), 1998. 63(7): p. 854-65.
7. Visconti, R. and D. Grieco, New insights on oxidative stress in cancer. Curr Opin Drug Discov Devel, 2009. 12(2): p. 240-5.
8. Coussens, L.M. and Z. Werb, Inflammation and cancer. Nature, 2002. 420(6917): p. 860-7.
9. Shivappa, N., et al., Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr, 2014. 17(8): p. 1689-96.
10. Park, S.Y., et al., Diet Quality and Risk of Lung Cancer in the Multiethnic Cohort Study. Nutrients, 2021. 13(5).
11. Sadeghi, A., et al., Inflammatory Potential of Diet and Odds of Lung Cancer: A Case-Control Study. Nutr Cancer, 2022. 74(8): p. 2859-2867.
12. Maisonneuve, P., et al., Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study. Eur J Nutr, 2016. 55(3): p. 1069-79.
1. Siegel, R.L., et al., Cancer statistics, 2023. CA Cancer J Clin, 2023. 73(1): p. 17-48.
2. Islami, F., et al., Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin, 2018. 68(1): p. 31-54.
3. Bade, B.C. and C.S. Dela Cruz, Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med, 2020. 41(1): p. 1-24.
4. Grivennikov, S.I., F.R. Greten, and M. Karin, Immunity, inflammation, and cancer. Cell, 2010. 140(6): p. 883-99.
5. Kidane, D., et al., Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol, 2014. 49(2): p. 116-39.
6. Maeda, H. and T. Akaike, Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc), 1998. 63(7): p. 854-65.
7. Visconti, R. and D. Grieco, New insights on oxidative stress in cancer. Curr Opin Drug Discov Devel, 2009. 12(2): p. 240-5.
8. Coussens, L.M. and Z. Werb, Inflammation and cancer. Nature, 2002. 420(6917): p. 860-7.
9. Shivappa, N., et al., Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr, 2014. 17(8): p. 1689-96.
10. Park, S.Y., et al., Diet Quality and Risk of Lung Cancer in the Multiethnic Cohort Study. Nutrients, 2021. 13(5).
11. Sadeghi, A., et al., Inflammatory Potential of Diet and Odds of Lung Cancer: A Case-Control Study. Nutr Cancer, 2022. 74(8): p. 2859-2867.
12. Maisonneuve, P., et al., Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study. Eur J Nutr, 2016. 55(3): p. 1069-79.
Aims
To evaluate the potential impact of E-DII derived from both food and supplement, as well as the E-DII obtained from food only, on the incidence of lung cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO).
Collaborators
Yangpiaoyi Shi, Linglong Peng, Wanhao Tang, Zhiquan Xu, Yaxu Wang, Haitao Gu, et al.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Ling Xiang, Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.