Association Between Reproductive Factors and Lung Cancer Risk
Principal Investigator
Name
Sinbad Xia
Degrees
Ph.D
Institution
The First Affiliated Hospital, School of Medicine, Zhejiang University
Position Title
researcher
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1363
Initial CDAS Request Approval
Oct 24, 2023
Title
Association Between Reproductive Factors and Lung Cancer Risk
Summary
Lung cancer in women exhibits distinct characteristics compared to men. Previous studies have shown mixed results regarding the role of reproductive factors in lung cancer development.
This study will analyze data from PLCO cohort on participants’ age at enrollment, body mass index, family history of lung cancer, smoking habits, race, socioeconomic factors, and reproductive history. The primary outcome will be newly diagnosed primary invasive lung cancer during the follow-up period. A multivariate Cox proportional hazards regression model will be used to assess the relationship between reproductive factors and lung cancer risk. Statistical analyses will be conducted using R version 4.3.0, with a significance threshold set at P < 0.05.
This study will analyze data from PLCO cohort on participants’ age at enrollment, body mass index, family history of lung cancer, smoking habits, race, socioeconomic factors, and reproductive history. The primary outcome will be newly diagnosed primary invasive lung cancer during the follow-up period. A multivariate Cox proportional hazards regression model will be used to assess the relationship between reproductive factors and lung cancer risk. Statistical analyses will be conducted using R version 4.3.0, with a significance threshold set at P < 0.05.
Aims
To examine the association between specific reproductive factors and the risk of developing lung cancer.
Collaborators
Dr. Jianya,Zhou, The First Affiliated Hospital, School of Medicine, Zhejiang University