Associations of dietary carrot/carotene intakes with risk of cancer and overall and cause-specific mortality: results from the PLCO Cancer Screening Trial
Principal Investigator
Name
Yadong Li
Degrees
M.M
Institution
The Second Affiliated Hospital of chongqing medical university
Position Title
Dr
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1266
Initial CDAS Request Approval
Jul 6, 2023
Title
Associations of dietary carrot/carotene intakes with risk of cancer and overall and cause-specific mortality: results from the PLCO Cancer Screening Trial
Summary
Carrot has high amounts of carotenoid antioxidants, including α- and -β-carotene, which might play an important role in cancer prevention [1]. There are various important biological functions, among which antioxidation is particularly important to human health. Specifically, some studies found that carotenoid was able to inhibit oxidative damage to DNA at low concentrations, which had been hypothesized to be anticancer effect [2,3]. Another study reported that higher concentrations of serum b-carotene were significantly associated with an increased risk of cardiovascular mortality among individuals with diabetes [4].
Therefore, based on the in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, this project sought to investigate the association between dietary carrot/carotene intakes and incidence of cancers, such as kidney cancer, breast cancer and so on. Moreover, we also explore investigate the association between dietary carrot/carotene intakes and overall and cause-specific mortality, including cardiovascular disease, cancer, and so on.
References:
1. Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005; 26:459–516.
2. Frei B. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. (1994) 97:5S−13S; discussion 22S−8S.
3. Shin J, Song MH, Oh JW, Keum YS, Saini RK. Pro-oxidant actions of carotenoids in triggering apoptosis of cancer cells: a review of emerging evidence. Antioxidants. (2020) 9:532.
4. Qiu ZX, Chen X, Geng TT et al. Associations of Serum Carotenoids With Risk of Cardiovascular Mortality Among Individuals With Type 2 Diabetes: Results From NHANES. [J]. Diabetes Care, 2022, 45: 1453-1461.
Therefore, based on the in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, this project sought to investigate the association between dietary carrot/carotene intakes and incidence of cancers, such as kidney cancer, breast cancer and so on. Moreover, we also explore investigate the association between dietary carrot/carotene intakes and overall and cause-specific mortality, including cardiovascular disease, cancer, and so on.
References:
1. Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005; 26:459–516.
2. Frei B. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. (1994) 97:5S−13S; discussion 22S−8S.
3. Shin J, Song MH, Oh JW, Keum YS, Saini RK. Pro-oxidant actions of carotenoids in triggering apoptosis of cancer cells: a review of emerging evidence. Antioxidants. (2020) 9:532.
4. Qiu ZX, Chen X, Geng TT et al. Associations of Serum Carotenoids With Risk of Cardiovascular Mortality Among Individuals With Type 2 Diabetes: Results From NHANES. [J]. Diabetes Care, 2022, 45: 1453-1461.
Aims
To investigate the prospective associations between intake of carrot/carotene and incidence of cancer, including individuals with diabetes.
To investigate the prospective associations between intake of carrot/carotene and overall and cause-specific mortality among US population, including individuals with diabetes.
Collaborators
(1) Chuan Liu, Department of urology , the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
(2) Zheng-Ju Ren, Department of urology , the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, Ch