Higher dietary anthocyanidins is associated with reduced risk of biliary cancer in the PLCO Cancer Screening Trial
Principal Investigator
Name
Ling Xiang
Degrees
Ph.D.
Institution
Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1257
Initial CDAS Request Approval
Jun 22, 2023
Title
Higher dietary anthocyanidins is associated with reduced risk of biliary cancer in the PLCO Cancer Screening Trial
Summary
Globally, biliary cancer is insidious and also poses a serious threat to the lives of patients. Anthocyanin is a water-soluble flavonoid. Anthocyanins are water-soluble flavonoids (1), and anthocyanins are in the form of glycosides (2). Studies have shown that anthocyanins are involved in many health-promoting activities and have antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer effects (3,4). Anthocyanins reduce tumor cell proliferation by blocking activation of the mitogen-activated protein kinase (MAPK) pathway (5). The association of dietary anthocyanidins with a variety of cancers has been investigated. However, the relationship between dietary anthocyanidins and biliary cancer risk is still unclear. we performed this study to investigate this relationship.
1. Pieńkowska N, Bartosz G, Furdak P, Sadowska-Bartosz I. Delphinidin Increases the Sensitivity of Ovarian Cancer Cell Lines to 3-Bromopyruvate. Int J Mol Sci. 2021 Jan 12;22(2):709.
2. Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res. 2017;61(1):1361779.
3. Chen Z, Zhang R, Shi W, Li L, Liu H, Liu Z, et al. The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides. J Agric Food Chem. 2019 Oct 16;67(41):11288–306.
4. Hair R, Sakaki JR, Chun OK. Anthocyanins, Microbiome and Health Benefits in Aging. Mol Basel Switz. 2021 Jan 21;26(3):537.
5. Wang LS, Stoner GD. Anthocyanins and their role in cancer prevention. Cancer Lett. 2008 Oct 8;269(2):281–90.
1. Pieńkowska N, Bartosz G, Furdak P, Sadowska-Bartosz I. Delphinidin Increases the Sensitivity of Ovarian Cancer Cell Lines to 3-Bromopyruvate. Int J Mol Sci. 2021 Jan 12;22(2):709.
2. Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res. 2017;61(1):1361779.
3. Chen Z, Zhang R, Shi W, Li L, Liu H, Liu Z, et al. The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides. J Agric Food Chem. 2019 Oct 16;67(41):11288–306.
4. Hair R, Sakaki JR, Chun OK. Anthocyanins, Microbiome and Health Benefits in Aging. Mol Basel Switz. 2021 Jan 21;26(3):537.
5. Wang LS, Stoner GD. Anthocyanins and their role in cancer prevention. Cancer Lett. 2008 Oct 8;269(2):281–90.
Aims
To investigate whether dietary anthocyanidins is associated with biliary cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Collaborators
Linglong Peng, Dabin Wu, Haitao Gu, Yaxu Wang. Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Related Publications
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Association between dietary anthocyanidins and biliary cancer risk in 98,458 participants: Results from a prospective study.
Xiang L, Wu D, Xu Z, Tang Y, He H, Wang Y, Gu H, Peng L
Cancer Epidemiol Biomarkers Prev. 2023 Nov 8 PUBMED