Association between BMI, Weight Change and Risk of Lung Cancer in the PLCO Cancer Screening Trial
Principal Investigator
Name
Yixiang Zhang
Degrees
Ph.D
Institution
The Second Affiliated Hospital of Fujian Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1194
Initial CDAS Request Approval
Apr 10, 2023
Title
Association between BMI, Weight Change and Risk of Lung Cancer in the PLCO Cancer Screening Trial
Summary
Smoking is the main risk factor for the development of lung cancer. Non-tobacco risk factors include genetics, environment, chronic lung disease and other lifestyles[1]. A number of epidemiological studies also indicated an association between body mass index (BMI) and lung cancer risk[2]. To date, the association between obesity and lung cancer risk has been studied primarily based on one-time measurements, and the dynamics of weight over time or the long-term effects of fat gain/underweight have not been adequately considered in previous studies. Although information is very limited, there is evidence that increased adult BMI is negatively associated with lung cancer risk[3].
In this study, we will estimate the association between events and lung cancer risk associated with BMI at ages 20 and 50 years in the PLCO cancer screening trial, and the association between weight change (increase and decrease) and lung cancer risk from age 20 to 50 years and from age 50 years to baseline (55-74 years). We will adjust for multiple potential confounders for analysis and perform subgroup analyses by smoking status and histological subtype. We anticipate that the findings may provide further insight into the role of obesity and weight change in lung carcinogenesis.
[1]Schabath MB, Cote ML. Cancer Progress and Priorities: Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2019;28(10):1563-1579.
[2]Yang Y, Dong J, Sun K, et al. Obesity and incidence of lung cancer: a meta-analysis. Int J Cancer. 2013;132(5):1162-1169.
[3]Tarleton HP, Park SL, Zhu WM, et al. Body mass index change in adulthood and lung and upper aerodigestive tract cancers. Int J Cancer. 2012;131(6):1407-1416.
In this study, we will estimate the association between events and lung cancer risk associated with BMI at ages 20 and 50 years in the PLCO cancer screening trial, and the association between weight change (increase and decrease) and lung cancer risk from age 20 to 50 years and from age 50 years to baseline (55-74 years). We will adjust for multiple potential confounders for analysis and perform subgroup analyses by smoking status and histological subtype. We anticipate that the findings may provide further insight into the role of obesity and weight change in lung carcinogenesis.
[1]Schabath MB, Cote ML. Cancer Progress and Priorities: Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2019;28(10):1563-1579.
[2]Yang Y, Dong J, Sun K, et al. Obesity and incidence of lung cancer: a meta-analysis. Int J Cancer. 2013;132(5):1162-1169.
[3]Tarleton HP, Park SL, Zhu WM, et al. Body mass index change in adulthood and lung and upper aerodigestive tract cancers. Int J Cancer. 2012;131(6):1407-1416.
Aims
1.To assess the association between BMI-related events and lung cancer risk at age 20 and 50.
2.To assess the association between weight change (increase and decrease) and the risk of developing lung cancer from age 20 to 50 and from age 50 to baseline age (55-74).
3. Association was assessed by smoking status and histological subtype.
Collaborators
Xiaoyang Chen(The Second Affiliated Hospital of Fujian Medical University, Quanzhou)
Yifu Zeng (Cyberspace Institute of Advanced Technology, Guangzhou University, Guangzhou)
Qingquan Chen, Kang Yang, Yao Chen(Fujian Medical University, Fuzhou)