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Longitudinal study on the growth and evolution of SSN

Principal Investigator
Name
Li Zhang
Degrees
M.D.
Institution
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Position Title
Associate chief physician
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-1016
Initial CDAS Request Approval
Feb 21, 2023
Title
Longitudinal study on the growth and evolution of SSN
Summary
In clinical work, due to the complex situation of patients, the treatment strategy of pulmonary subsolid nodules (SSNs) is mostly formulated by the doctors according to their own experience, which lacks scientific basis. This study aims to use radiomics and liquid biopsy techniques to dynamically observe the growth of SSN. On this basis, Bayesian network and other technologies were used to couple the clinical, imaging, omics, gene characteristics to establish an invasive time series evolution model of SSN. To provide a scientific basis for the scientific management and the timing of clinical treatment of SSN , so as to promote the rational allocation of medical resources.
Aims

(1) To clarify the clinical, imaging and gene characteristics of SSN, and to establish the screening and diagnostic criteria of SSN;
(2) To determine the evolution trajectory of SSN;
(3) To determine the correlation between gene characteristics of SSN and imaging omics characteristics based on CT images of lesions;
(4) To establish a sequential evolution model of SSN based on clinical, imaging, and gene characteristics.

Collaborators

(1) Meng Li, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
(2) Mengwen Liu, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
(3) Jiuming Jiang, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
(4) Xue Zhang, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
(5) Ziqiao Yin, Beihang University

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