Study
PLCO
(Learn more about this study)
Project ID
PLCO-1165
Initial CDAS Request Approval
Feb 14, 2023
Title
Phenome-Wide Association Studies of the immune-related genetic variants
Summary
A wide range of diseases are linked to the immune function alteration, such as cancer, asthma and chronic obstructive pulmonary disease (COPD). Identifying the immune-related biomarkers (e.g. genetic variant, laboratory biomarkers) is very important to find the individuals with high-risk and develop strategies for disease prevention. Thus, we aim to conduct a Phenome-Wide Association Study between various phenotypes (e.g. disease risk, inflammation biomarkers) and immune-related genetic variants in GERA. We are going to identify the association between genetic variants of immune related genes across different phenotypes such as cancer and respiratory diseases, perform the phenome-wide Mendelian-randomization study on the immune mediators and develop a bioinformatics algorithm to evaluate their immune priority index among different traits. Identification of biomarkers including genetic variants, genes, pathways for different phenotypes will help researchers further understand the disease entity and focus on drug targets for treatment.
Aims
We aim to evaluate the associations between phenotypes and immune-related genetic variants in GERA. We are going to identify the association between genetic variants in immune function genes (fGene) and immune phenotype genes (pGene) across different traits, perform the phenome-wide Mendelian-randomization study on the immune mediators and develop a bioinformatics algorithm and evaluate the immune priority index among different traits. Identification of genetic variants, genes, pathways and immune priority index for different phenotypes will help researchers further understand the disease entity and focus on drug targets for treatment.
Collaborators
Sipeng Shen
Associate professor
NANJING MEDICAL UNIVERSITY
101 longmian ave
Nanjing, 211100 CHINA
Phone: 86-86868436 Email: sshen@njmu.edu.cn
