Chengcheng Liu

Ph.D

The Second Affiliated Hospital, Zhejiang University School of Medicine

Assistant researcher

PLCO (Learn more about this study)

PLCO-1082

Oct 27, 2022

Diabetes risk reduction diet and colorectal carcinogenesis: a prospective cohort study

As one of the most five commonly cancers, colorectal cancer causes large disease burden. Colorectal cancer (CRC) is the third most common cancer, with more than 104,000 new cases of colon cancer and 43,340 new cases of rectal cancer diagnosed in the United States in 2020. Type 2 diabetes (T2D) is a serious threat to human health and is a predisposing factor for many chronic diseases including cardiovascular disease and cancer[1]. Generally, a healthy diet that can improve insulin sensitivity and reduce inflammation is thought be beneficial to prevent cancer. Jinnie et al. created a dietary diabetes risk reduction score (DDRRS), which is characterized by high intakes of cereal fiber, polyunsaturated fats, nuts, and coffee; and low amounts of carbohydrates, trans fat, sweets, and red and processed meat [2]. Higher DDRRS have been associated with lower risks of hepatocellular carcinoma [3] and breast cancer [4]. However, to the best of our knowledge, no epidemiological studies have evaluated the potential association of DDRRS with the risk of colorectal cancer. Therefore, our current objective is to examine the association between the potential in regulating insulin and inflammation of diet, as estimated by the DDRRS, and colorectal cancer incidence using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide sufficient power and robust evidence in guiding cancer prevention.

References
[1] Parvin M, Zahra B, Asghar G, et al. Type 2 Diabetes and Cancer: An Overview of Epidemiological Evidence and Potential Mechanisms. Crit Rev Oncog. 2019;24(3):223-233.
[2] Rhee JJ, Mattei J, Hughes MD, et al. Dietary diabetes risk reduction score, race and ethnicity, and risk of type 2 diabetes in women. Diabetes Care. 2015;38(4):596-603.
[3] Luo X, Sui J, Yang W, et al. Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women. Am J Gastroenterol. 2019;114(12):1870-1877.
[4] Kang JH, Peng C, Rhee JJ, et al. Prospective study of a diabetes risk reduction diet and the risk of breast cancer. Am J Clin Nutr. 2020 Dec 10;112(6):1492-1503.