Linglong Peng

Ph.D.

The Second Affiliated Hospital of Chongqing Medical University

Dr.

PLCO (Learn more about this study)

PLCO-1070

Oct 11, 2022

The association of the sulfur microbial diet with colorectal adenoma and recurrent adenoma risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Colorectal cancer (CRC) is the third most common and third deadliest form of cancer in the United States. Diet has received increasing attention in recent years as an important means of cancer prevention. And some specific dietary patterns will produce hydrogen sulfide, a gastrointestinal carcinogen that is difficult to directly measure, through gastrointestinal microorganisms. Recently, related studies have established a sulfur microbial diet score and confirmed that it is positively correlated to colorectal cancer and colorectal adenomas(1-3). However, due to population constraints, the correlation between sulfur microbial diet scores and colorectal adenomas in people over 50 years of age has not been confirmed(3). We will further optimize the sulfur microbial diet score by analyzing the existing sulfur microbial diet score composition, combined with the specific role of diet composition in colorectal cancer. And use data such as DQX, SCU, and BQ in the PLCO database to explore the specific association of sulfur microbial diet scores with the incidence of adenoma and recurrent adenoma in people older than 50 years of age.

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2. Wang Y, Nguyen LH, Mehta RS, Song M, Huttenhower C, Chan AT. Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. JAMA Netw Open. 2021;4(11):e2134308.
3. Nguyen LH, Cao Y, Hur J, Mehta RS, Sikavi DR, Wang Y, et al. The Sulfur Microbial Diet Is Associated With Increased Risk of Early-Onset Colorectal Cancer Precursors. Gastroenterology. 2021;161(5):1423-32 e4.