Skip to Main Content

An official website of the United States government

Diabetes risk reduction diet and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Postdoctor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-812
Initial CDAS Request Approval
Jul 22, 2021
Title
Diabetes risk reduction diet and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Summary
Type 2 diabetes is a major health issue worldwide and is a predisposing factor for several chronic diseases, such as cardiovascular disease and cancer. Cardiovascular disease represents the main global cause of death, currently accounting for >17.3 million deaths annually; this figure is predicted to rise to >23.6 million by 2030 [1]. Generally, a healthy diet that can improve insulin sensitivity and reduce inflammation is thought be beneficial to prevent cancer occurrence. Previously, Jinnie et al. created a dietary diabetes risk reduction score (DDRRS), which is characterized by high intakes of cereal fiber, polyunsaturated fats, nuts, and coffee; and low amounts of carbohydrates, trans fat, sweets, and red and processed meat [2]. Higher DDRRSs have been associated with lower risks of hepatocellular carcinoma [3] and breast cancer [4]. However, to the best of our knowledge, no epidemiological studies have evaluated the potential association of DDRRS with the risk of pancreatic cancer. Therefore, we sought to fill this gap using prospective data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
References
[1] Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics–2015 update: a report from the American Heart Association. Circulation. 2015;131(4):e29-e322.
[2] Rhee JJ, Mattei J, Hughes MD, Hu FB, Willett WC. Dietary diabetes risk reduction score, race and ethnicity, and risk of type 2 diabetes in women. Diabetes Care. 2015;38(4):596-603.
[3] Luo X, Sui J, Yang W, et al. Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women. Am J Gastroenterol. 2019;114(12):1870-1877.
[4] Kang JH, Peng C, Rhee JJ, et al. Prospective study of a diabetes risk reduction diet and the risk of breast cancer [published online ahead of print, 2020 Oct 6]. Am J Clin Nutr. 2020;nqaa268.
Aims

(1) To clarify the potential association between dietary diabetes risk reduction score and the risk of pancreatic cancer.
(2) To explore the potential dose-response relationship between dietary diabetes risk reduction score and the risk of pancreatic cancer.

Collaborators

(1) Yang Peng, Department of Geriatrics, the Fifth People’s Hospital of Chengdu, Chengdu, China
(2) Chun-Rui Wang, Department of Infectious disease, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
(3) Fa-Bao Hao, Department of Neurosurgery, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao, Shandong, China

Related Publications