Marital status and all cause and cause-specific mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Principal Investigator
Name
danhua wang
Degrees
Ph.D.
Institution
Department of Public Health and Preventive Medicine, Kangda College of Nanjing Medical University
Position Title
Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-804
Initial CDAS Request Approval
Jul 2, 2021
Title
Marital status and all cause and cause-specific mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Summary
It is well known that marital status is significantly associated with health, including the risk of mortality. Marital status has been showed to affect the natural history of many diseases, including several cancers[1]. Generally, married people have better health profiles than other people, including those who are divorced, separated, or widowed[2]. Married patients have improved survival in gallbladder cancer[3], colorectal cancer[4], prostate cancer[5], and so on.
To our knowledge, an integrated analysis of association between marital status and overall mortality is lacking in middle-aged and elderly population. Because investigation of total and cause-specific mortality would be informative for elucidation of the role of marital status in overall health, we propose to comprehensively examine the associations between differential marital status and risk of overall and cause-specific mortality. We will further address the associations across key population subgroups.
1. Sammon JD, Morgan M, Djahangirian O, Trinh QD, Sun M, Ghani KR, Jeong W, Jhaveri J, Ehlert M, Schmitges J, Bianchi M, Shariat SF, Perrotte P, Rogers CG, Peabody JO, Menon M, Karakiewicz PI. Marital status: a gender-independent risk factor for poorer survival after radical cystectomy. BJU Int. 2012 Nov;110(9):1301-9.
2. Berntsen KN, Kravdal O. The relationship between mortality and time since divorce, widowhood or remarriage in Norway. Social science & medicine (1982). 2012; 75: 2267-74.
3. Bai DS, Chen P, Qian JJ, Jin SJ, Jiang GQ. Effect of marital status on the survival of patients with gallbladder cancer treated with surgical resection: a population-based study. Oncotarget. 2017 Apr 18;8(16):26404-26413.
4. Yang CC, Cheng LC, Lin YW, Wang SC, Ke TM, Huang CI, Su YC, Tai MH. The impact of marital status on survival in patients with surgically treated colon cancer. Medicine (Baltimore). 2019 Mar;98(11):e14856.
5. Huang TB, Zhou GC, Dong CP, Wang LP, Luan Y, Ye JT, Gu X, Yao XD, Zheng JH, Ding XF. Marital status independently predicts prostate cancer survival in men who underwent radical prostatectomy: An analysis of 95,846 individuals. Oncol Lett. 2018 Apr;15(4):4737-4744.
To our knowledge, an integrated analysis of association between marital status and overall mortality is lacking in middle-aged and elderly population. Because investigation of total and cause-specific mortality would be informative for elucidation of the role of marital status in overall health, we propose to comprehensively examine the associations between differential marital status and risk of overall and cause-specific mortality. We will further address the associations across key population subgroups.
1. Sammon JD, Morgan M, Djahangirian O, Trinh QD, Sun M, Ghani KR, Jeong W, Jhaveri J, Ehlert M, Schmitges J, Bianchi M, Shariat SF, Perrotte P, Rogers CG, Peabody JO, Menon M, Karakiewicz PI. Marital status: a gender-independent risk factor for poorer survival after radical cystectomy. BJU Int. 2012 Nov;110(9):1301-9.
2. Berntsen KN, Kravdal O. The relationship between mortality and time since divorce, widowhood or remarriage in Norway. Social science & medicine (1982). 2012; 75: 2267-74.
3. Bai DS, Chen P, Qian JJ, Jin SJ, Jiang GQ. Effect of marital status on the survival of patients with gallbladder cancer treated with surgical resection: a population-based study. Oncotarget. 2017 Apr 18;8(16):26404-26413.
4. Yang CC, Cheng LC, Lin YW, Wang SC, Ke TM, Huang CI, Su YC, Tai MH. The impact of marital status on survival in patients with surgically treated colon cancer. Medicine (Baltimore). 2019 Mar;98(11):e14856.
5. Huang TB, Zhou GC, Dong CP, Wang LP, Luan Y, Ye JT, Gu X, Yao XD, Zheng JH, Ding XF. Marital status independently predicts prostate cancer survival in men who underwent radical prostatectomy: An analysis of 95,846 individuals. Oncol Lett. 2018 Apr;15(4):4737-4744.
Aims
1. To evaluate the associations between differential marital status and overall and cause-specific mortality.
2. To investigate the associations between differential marital status and overall and cause-specific mortality across key population subgroups.
3. To examine whether the marital status is related to life expectancy in middle-aged and elderly population
Collaborators
Xianzhen Peng, Kangda College of Nanjing Medical University