Tingting Wang

MD

Department of Nurtrition, First Affiliated Hospital, School of Medicine, Zhejiang University

Registered dietitian of China

PLCO (Learn more about this study)

PLCO-750

Mar 16, 2021

Dairy consumption and risk of esophageal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Esophageal cancer (EC) is one kind of high incidence of upper digestive tract cancers worldwide. It is the sixth most common cause of cancer-related death in the world. GLOBOCAN 2018 has reported an estimated 572,034 new cases and 508,585 deaths occurred for both sexes[1]. EC is mainly of two types, squamous cell carcinoma and adenocarcinoma. The relationship of food intake and cancer has been studied in different areas of the world, including animal fats or saturated fats, processed meat showed a positive correlation with a higher incidence of EC[2]. Milk and dairy consumption are important components of diets in some areas of the world. They have been widely studied for cancers like breast, prostate and colon, but their direct correlation with the development of EC have yielded inconsistent results. Silvera finding that high-fat dairy products are associated with an increased risk of both subtypes of EC, however, others found no association with dairy products[3] or a reduced risk with higher milk consumption[4].Therefore, we propose to study the association between dairy consumption and EC in PLCO subjects.

[1]Freddie, Bray, Jacques, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.[J]. CA: a cancer journal for clinicians, 2018.
[2]Navarro Silvera SA, Mayne ST, Risch H et al. Food group intake and risk of subtypes of esophageal and gastric cancer. Int J Cancer 2008; 123: 852–60
[3]Bosetti C, La Vecchia C, Talamini R, et al.Food groups and risk of squamous cell esophageal cancer in northern Italy[J]. Int J Cancer 2000;87:289–94
[4]Levi F, Pasche C, Lucchini F, Bosetti C, et al. Food groups and oesophageal cancer risk in Vaud, Switzerland[J]. Eur J Cancer Prev 2000;9:257–63.