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Initial CDAS Request Approval
Nov 19, 2020
Hormone replacement therapy use and risk of breast cancer incidence and death
Incidence of breast cancer in the United States has been increasing over the last several decades. Revealing mechanisms for cancer prevention is a significant public health need. The long-term use of hormone replacement therapy (HRT) was associated with increased breast cancer risk. The 2 main hormones used in HRT are oestrogen and progestogen. However, the potential risk of different regimens are unknown. PLCO trial is an ideal cohort to observed long-term different HRT regimens and risk of breast cancer.
Assessing the risk of breast cancer incidence and death from HRT involving either taking both of these hormones (combined HRT) or just taking oestrogen (oestrogen-only HRT).