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Vitamin K intake and pancreatic cancer incidence and death in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial

Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D
Institution
Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-672
Initial CDAS Request Approval
Oct 8, 2020
Title
Vitamin K intake and pancreatic cancer incidence and death in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial
Summary
Vitamin K has two forms, namely, phylloquinone (vitamin K1) and menaquinones (vitamin K2). Many studies have found that vitamin K2 at pharmacological doses confer clinical benefits on osteoporosis and cancer. Moreover, epidemiological studies have found that increasing intakes of vitamin K is associated with a reduced risk of cancer. However, to our knowledge, no epidemiological studies have investigated the association between vitamin K intake and pancreatic cancer incidence and mortality. Here, we propose a hypothesis that increasing intakes of vitamin K is associated with reduced risks of pancreatic cancer incidence and mortality. To verify this hypothesis, we used prospective data from PLCO Cancer Screening Trial to perform a secondary analysis.
Aims

(1) To examine the association of vitamin K intake (total vitamin K, vitamin K1 and vitamin K2 ) and pancreatic cancer incidence;
(2) To examine the association of vitamin K intake (total vitamin K, vitamin K1 and vitamin K2 ) and pancreatic cancer mortality;
(3)To examine the potential dose-response relationship between vitamin K intake (total vitamin K, vitamin K1 and vitamin K2 ) and pancreatic cancer incidence and mortality.

Collaborators

(1) Kang Wang, Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
(2) Jing-Jing Wu, Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China

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