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Chocolate consumption and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-645
Initial CDAS Request Approval
Jul 17, 2020
Title
Chocolate consumption and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Summary
Chocolate is one of the most popular confectionery products all over the world, especially in Western countries. A growing body of evidence has revealed the beneficial effects of chocolate on cardiovascular health. For example, chocolate consumption has been associated with reduced risks of stroke, coronary heart disease, and heart failure (1-3). However, evidence on chocolate consumption and mortality in the general population is sparse and inconclusive. Specifically, a study of 20951 men and women observed that higher chocolate consumption was significantly associated with lower mortality from cardiovascular disease (4), whereas such a significant association was not observed in another study of 34489 postmenopausal women (5). In addition, to our knowledge, no study has examined the effects of chocolate consumption on all-cause and non-cardiovascular mortality in the general population.
References:
1. Yuan S, Li X, Jin Y, Lu J. Chocolate Consumption and Risk of Coronary Heart Disease, Stroke, and Diabetes: A Meta-Analysis of Prospective Studies. Nutrients. 2017;9.
2. Gong F, Yao S, Wan J, Gan X. Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies. Nutrients. 2017;9.
3. Ren Y, Liu Y, Sun XZ, Wang BY, Zhao Y, Liu DC et al. Chocolate consumption and risk of cardiovascular diseases: a meta-analysis of prospective studies. Heart. 2019;105:49-55.
4. Kwok CS, Boekholdt SM, Lentjes MA, Loke YK, Luben RN, Yeong JK et al. Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women. Heart. 2015;101:1279-87.
5. Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85:895-909.
Aims

(1) To examine the association of chocolate consumption with mortality;
(2) To describe the potential dose-response relationship between chocolate consumption and mortality;
(3) To identify the potential effect modifiers of the association between chocolate consumption and mortality.

Collaborators

(1) Tian-Yang Hu; Institution: The Second Affiliated Hospital of Chongqing Medical University
(2) Peng-Fei Yang; Institution: The Second Affiliated Hospital of Chongqing Medical University
(3) Kang Wang; Institution: The First Affiliated Hospital of Chongqing Medical University

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