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Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Resident physician
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-642
Initial CDAS Request Approval
Jun 30, 2020
Title
Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Summary
Pancreatic cancer is the fourth most common cause of cancer-associated death in the US 1. Lifestyle factors have been suggested to play a critical role 2, 3. Therefore, investigating the association between lifestyle patterns and pancreatic cancer risk is essential for understanding the role of lifestyle behaviors in the etiology of this cancer 4. The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) proposed an updated set of 10 recommendations for cancer prevention in 2018 5. To date, two studies have investigated the association between adherence to the 2007 WCRF/AICR recommendations and pancreatic cancer risk in the European population, but presented inconsistent results 6, 7. Specifically, a 2012 prospective study on this topic revealed a null association 7, whereas a subsequent case-control study observed that adherence to the WCRF/AICR recommendations conferred a reduced risk of developing pancreatic cancer 6. To our knowledge, no study has explored this topic in the US population; moreover, whether adherence to the latest WCRF/AICR recommendations confers a reduced pancreatic cancer risk has not been determined.
References:
1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020; 70(1): 7-30
2. Maisonneuve P. Epidemiology and burden of pancreatic cancer. Presse Med. 2019; 48(3 Pt 2): e113-e123.
3. Tsai HJ, Chang JS. Environmental Risk Factors of Pancreatic Cancer. J Clin Med. 2019; 8(9).
4. Salem AA, Mackenzie GG. Pancreatic cancer: A critical review of dietary risk. Nutr Res. 2018; 52: 1-13.
5. World Cancer Research Fund/American Institute for Cancer Research. Continuous update project expert report 2018. Diet, nutrition, physical activity and cancer: a global perspective. https://www.wcrf.org/dietandcancer. Accessed on March 15, 2020.
6. Lucas AL, Bravi F, Boffetta P, Polesel J, Serraino D, La Vecchia C et al. Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk. Cancer Epidemiol. 2016; 40: 15-21.
7. Romaguera D, Vergnaud AC, Peeters PH, van Gils CH, Chan DS, Ferrari P et al. Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study. Am J Clin Nutr. 2012; 96(1): 150-163.
Aims

We aimed to examine the hypothesis that adherence to the 2018 WCRF/AICR recommendations is associated with reduced risks of pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Collaborators

(1) You-Qi-Le Wu, Department of Clinical Nutrition, Mianyang Maternal and Child Health Hospital, Mianyang, Sichuan, China
(2) Lun Wan, Department of Hepatobiliary Surgery, the People’s Hospital of Dazu District, Chongqing 402360, China.