(Learn more about this study)
Initial CDAS Request Approval
Apr 23, 2020
The association of dietary fats and carbohydrates with total and cause-specific mortality in PLCO cohort
Diet plays an important role in the public health, and suboptimal nutrition is estimated as the first leading cause of death worldwide. Longstanding controversies have focused on the effects of dietary fat and carbohydrate on health outcomes. Some dietary guidelines have continued to recommend a low-fat diet for prevention of chronic diseases, although inconsistent associations have been reported in previous publications. Similarly, the long-term associations of low-carbohydrate diets with health consequences also remain controversial. Therefore, we plan to perform an evaluation of dietary fats and carbohydrates associated with total and cause-specific mortality.
The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial is a randomized, controlled trial enrolling around 155,000 participants between November 1993 and July 2001, providing a comprehensive dataset for total and cause-specific mortality. In addition, diet information is also available in questionnaires, such as Dietary Questionnaire (DQX) and Diet History Questionnaire (DHQ).
We plan to systematically evaluate the associations between dietary fats and carbohydrates and total and cause-specific mortality (including cancer mortality, cardiovascular mortality, and other mortality).