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Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-559
Initial CDAS Request Approval
Dec 11, 2019
Title
Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Summary
Primary liver cancer (PLC) is a commonly diagnosed and highly lethal malignancy worldwide. Observational studies have found that higher magnesium intake was associated with lower risks of breast cancer 1, colorectal cancer 2, and pancreatic cancer 3. To the best of our knowledge, no prospective studies have investigated the association between magnesium intake and risks of PLC incidence and mortality. In the context of the high prevalence of magnesium deficiency and the huge burden of PLC across many countries, clarifying potential associations of magnesium intake with PLC incidence and mortality will have important public health implications.
References:
1. Huang WQ, Long WQ, Mo XF, et al. Direct and indirect associations between dietary magnesium intake and breast cancer risk. Sci Rep. 2019; 9: 5764.
2. Meng Y, Sun J, Yu J, Wang C, Su J. Dietary Intakes of Calcium, Iron, Magnesium, and Potassium Elements and the Risk of Colorectal Cancer: a Meta-Analysis. Biol Trace Elem Res. 2019; 189: 325-335.
3. Dibaba D, Xun P, Yokota K, White E, He K. Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study. Br J Cancer. 2015; 113: 1615-1621.
Aims

We used prospective data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial to demonstrate whether higher magnesium intake from diet and supplements was associated with decreased risks of PLC incidence and mortality in the US population.

Collaborators

1) Jian-Ping Gong, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University.
(2) Yi-Lin Wu,Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University.
(3) Kang Wang,Department of Breast and Endocrine Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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