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Principal Investigator
Name
Zhuyue Li
Degrees
Ph.D.
Institution
West China Hospital
Position Title
Dr.
Email
About this Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-536
Title
Inflammatory potential of diet and risk of ovarian cancer by menopausal status in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
Summary

As the most dangerous female cancer, the incidence of ovarian cancer will increase to 371,000 a year and deaths will increase to 254,000 worldwide. Besides reproductive and hormonal factors and a few strongly penetrant genes, not much is known with certainty about the causes of ovarian cancer. However, evidence suggests a role for the ability of diet to modulate inflammation in the etiology of this disease. A typical human diet included both proinflammatory and anti-inflammatory foods and nutrients. Therefore, a dietary pattern approach, which provides insights into the complex interactions among dietary components, may guide dietary intervention strategies aimed at the primary prevention of this malignancy.
Previously case-control studies had examined the association between dietary inflammatory index (DII) score and risk of ovarian cancer. In conclusion, results suggest that a pro-inflammatory diet modestly increases the risk of developing ovarian cancer, however, their findings should be propectively validated in PLCO study.
Thus, our current objective is to examine the association between inflammatory potential of diet, as estimated by the DII, and ovarian cancer risk using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide ample power to conduct subgroup analysis by lifestyle factors.

Aims

1) To examine the association between inflammatory potential of diet, as estimated by the DII, and ovarian cancer risk using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort
2) To evaluate the association of the inflammatory potential of diet and risk of breast cancer subsets by lifestyle factors.

Collaborators

Kang Wang
Department of the Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical university