Genetic variant in the vitamin D pathway in relation to breast cancer risk and survival：results from a large-scale prospective cohort study
Principal Investigator
Name
Kang Wang
Degrees
M.D
Institution
Department of the Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical university
Position Title
MD
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-442
Initial CDAS Request Approval
Jan 28, 2019
Title
Genetic variant in the vitamin D pathway in relation to breast cancer risk and survival：results from a large-scale prospective cohort study
Summary
Vitamin D may protect against poor health outcomes, including heart disease, diabetes, certain cancers, and overall mortality, and numerous epidemiologic studies have found an association between higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower breast cancer risk. Genetic polymorphisms involved in the vitamin D pathway may affect its activities, and therefore may be related to breast cancer if vitamin D indeed plays a role in the disease.
Aims
To examine the role of genetic polymorphisms involved in the vitamin D pathway in breast cancer
To examine interactions between Genetic variant and serum 25-hydroxyvitamin D which were associated with breast cancer risk and survival
Collaborators
Yang Shi ，Division of Biostatistics and Data Science, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Zhu-Yue Li，West China Hospital / West China School of Nursing