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Inflammatory potential of diet and risk of breast cancer by menopausal status in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

Principal Investigator
Name
Kang Wang
Degrees
M.D
Institution
Department of the Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical university
Position Title
MD
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-438
Initial CDAS Request Approval
Jan 15, 2019
Title
Inflammatory potential of diet and risk of breast cancer by menopausal status in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
Summary
As the most common female cancer, breast cancer is diagnosed in more than 266,120 patients in the United States each year. Besides reproductive and hormonal factors and a few strongly penetrant genes, not much is known with certainty about the causes of breast cancer. However, evidence suggests a role for the ability of diet to modulate inflammation in the etiology of this disease. A typical human diet included both proinflammatory and anti-inflammatory foods and nutrients. Therefore, a dietary pattern approach, which provides insights into the complex interactions among dietary components, may guide dietary intervention strategies aimed at the primary prevention of this malignancy.
Previously two studies had examined the association between dietary inflammatory index (DII) score and risk of breast in postmenopausal women. A prospective cohort study, SWLH, concluded that women who consumed a more proinflammatory diet appear to be at increased risk of breast cancer compared with women who consumed an anti-inflammatory diet, especially in postmenopausal women. Data from the Iowa Women's Health Study got similar results. However, a recent case-control study from Iran suggested that more proinflammatory diets, indicated by higher DII scores, may increase the odds of breast cancer, especially among premenopausal women.
Given these previous studies, our current objective is to examine the association between inflammatory potential of diet, as estimated by the DII, and breast cancer risk using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide ample power to conduct subgroup analysis by menopausal status.
Aims

1) To examine the association between inflammatory potential of diet, as estimated by the DII, and breast cancer risk using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort
2) To evaluate the association of the inflammatory potential of diet and risk of breast cancer subsets by menopausal status.

Collaborators

Yang Shi
Division of Biostatistics and Data Science, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Zhu-yue Li
West China Hospital / West China School of Nursing, Sichuan University, Chengdu, China;

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