Hongji Dai

Ph.D.

Tianjin Medical University Cancer Hospital & Institute

Associate Investigator

PLCO (Learn more about this study)

PLCO-376

Jun 21, 2018

Secular trend of age at menarche and age at menopause among women of different races

Hormone-related factors such as age at menarche and age at menopause could be associated with several cancers, e.g. breast, ovarian and prostate. As the economic growth and life style changes, hormone-related factors varies across generations. Age at menarche and age at menopause are two measurable factors that could reflect endogenous hormones levels. However, these data were limited in recent studies. In this study, we will explore secular trend of age at menarche and age at menopause, and investigate the related environmental and life style factors. Furthermore, we will examine the relationship between hormone-related factors with ovarian cancer risk and survival. This study will provide a clear description of age at menarche and age at menopause among women of different races.

First, we will investigate the secular trend of age at menarche and age at menopause among women of different generations. Second, we will compare differences of age at menarche and age at menopause and their related factors among women of different races, e.g. whites and Asians. Third, we will examine the relationship between several hormone-related factors (e.g., age at menarche, age at menopause and hormone treatment) with ovarian cancer risk and survival.

Additional analysis will look at lung and colorectal cancer risk and survival.