Gaoxiang Ma

Ph.D

China Pharmaceutical University

Prof.

PLCO (Learn more about this study)

PLCO-361

Apr 17, 2018

The association between age and prognosis among prostate cancer patients suffered from radiotherapy

Management of old men with prostate cancer is a growing clinical dilemma. Prostate cancer primarily affects old men, life expectancy is rapidly improving, and old patients are often excluded from clinical trials. Indeed, despite that almost a quarter of men diagnosed with prostate cancer are 75 years or older, none of the major clinical randomized trials comparing radical to conservative treatment included men older than 75 years. Some studies have investigated the association between age at diagnosis and prostate cancer death among men treated with curatively intended radiotherapy. But the conclusions were contradictory. Multicentric and a larger group of patients with follow-up information should be used to address this issue.

The lifestyle factor of diet is increasingly being studied for their associations with cancer. Epidemiological studies show that the inclusion of wholegrain, fibre, fruits, and vegetables within diets are associated with prostate cancer survival, with diet during early life having the strongest apparent association with cancer incidence.

The aim of this study was to investigate the association between age at diagnosis and prostate cancer death among among men treated with curatively intended radiotherapy, and to assess if it is independent of tumor characteristics, primary treatment, year of diagnosis, mode of detection and comorbidity.

The dietary, free psa and vitamin D data from PLCO are the important information for the prognosis of PCa among men treated with curatively intended radiotherapy.