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Change in smoking behaviors and BMI and their impact on the incidence and mortality of lung and colorectal cancer in the PLCO population

Principal Investigator
Name
Ji-Bin Li
Degrees
Ph.D
Institution
Sun Yat-sen University Cancer Center
Position Title
Research assistant
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-295
Initial CDAS Request Approval
Aug 9, 2017
Title
Change in smoking behaviors and BMI and their impact on the incidence and mortality of lung and colorectal cancer in the PLCO population
Summary
Lung and colorectal cancers are commonly diagnosed malignancy worldwide. The cancer statistics in China reported that lung cancer and colorectal cancer are two of the 5 most commonly diagnostic malignancy in 2015. Tobacco smoking and obesity, two major global health challenge, are commonly reported risk factors for lung and colorectal cancers. Around 90% of diagnoses of lung cancer are attributable to cigarette smoking. It has reported that adult weight gain has been associated with several types of cancers (e.g., esophagus, colorectal, prostate).

Engaging in screening for cancer may be served as a potential interventional method, which may call “Screening as Prevention”, especially for those who received abnormal screening or cancer-diagnosed results. Participants who involved in screening program may intentionally amend their risk behaviors/factors (i.e. quit smoking, reduce smoking intensity or frequency, control body weight, etc.) after the screening (or notified the screening abnormal results), to further reduce the probability of incidence and mortality from lung and colorectal cancers.

However, it is still unclear the extent to which participants who enrolled in the screening program controlled their smoking behaviors (e.g., smoking cessation, smoking intensity, duration, frequency) and body weight for all participants, positive-screening participants, and cancer-diagnosed participants, respectively. Moreover, it is still unclear how change in smoking behaviors and BMI relate to the incidence and mortality from lung and colorectal cancers for screening population. In this study, we primarily aim to estimate the impacts of change in smoking behaviors and BMI on the incidence and mortality from lung and colorectal cancer by using PLCO cohort dataset. The findings may provide the evidences for physicians to effectively motivate and teach their participants to reduce existing risk behaviors and improve their lifestyle by using the “screening moment” period.
Aims

The PLCO data are needed to conduct following specific aims:
1) to determine the extent to which participants changed their smoking behaviors from baseline questionnaire survey to follow-up questionnaire survey among all participants, positive-screening participants and cancer-diagnosed participants respectively, including smoking cessation, smoking intensity, smoking duration and frequency.
2) to estimate weight change (BMI in continuous variable and categorical variable) from baseline to follow-up.
3) to systematically examine the associations of change in smoking behaviors and change in BMI with risk of incidence and mortality from lung and colorectal cancer, after adjustment of potential confounders (including demographics, family history of cancer, medical conditions and history of disease, personal history of cancer).

Collaborators

Shao-Dong Hong, M.D, Department of Medical Oncology, Sun Yat-sen University Cancer Center
Yu-Jing Fang, Ph.D, associate professor, Department of Colorectal Surgery, Sun Yat-sen University Cancer Center

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