Meilin Wang

Ph.D.

Nanjing Medical Univeristy

Assistant Dean

PLCO (Learn more about this study)

PLCO-280

Jun 15, 2017

Evaluation of effects of dietary factors on the risk of colorectal cancer

Emerging evidences have demonstrated that both external exposure factors (e.g., dietary behaviors and colonoscopic surveillance) and internal exposure factors (e.g., vitamin D and hormone levels) could play important roles in the development and progression of colorectal cancer. In our previous study, we have found that individuals with a high level of BMI and estrogen had a higher incidence of colorectal cancer, whereas intake of aspirin, vitamin C, vitamin E and calcium supplements could reduce colorectal cancer risk (All these findings have not yet been published). Additionally, it has not reported that the PSA level be as a potential mediated factor on colorectal cancer risk. Besides, it seldom reported the interaction and mediation effect among multiple factors on colorectal cancer risk. We plan to use interaction analysis or/and mediation analysis to explain the effect of each risk factor on colorectal cancer, mainly including the potential factors of dietary behaviors, colonoscopic surveillance, multi-vitamins intakes and PSA level, and even the genetic variants. All these will helps to provide more comprehensive prevention strategies for colorectal cancer.