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A facile synthesis of 5'-end solid-anchored, 3'-end free oligodeoxyribonucleotides via the (5'-->3')-elongated phosphoramidite strategy.

Authors

Sakakura A, Hayakawa Y

Affiliations

  • Laboratory of Bioorganic Chemistry, Graduate School of Human Informatics, Nagoya University, Chikusa, Japan.

Abstract

It is demonstrated that not only N2- but also O6-protection of the guanine base is necessary for obtaining the oligodeoxyribonucleotides in high yields and at a high purity in the solid-phase synthesis via the (5'--> 3')-chain elongated phosphoramidite approach.

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Publication Details

PubMed ID
11393398

Digital Object Identifier
10.1081/NCN-100002082

Publication
Nucleosides Nucleotides Nucleic Acids. 2001 Mar; Volume 20 (Issue 3): Pages 213-27

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