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Randomized, Placebo-Controlled Trial of Linaclotide to Demonstrate Colorectal Bioactivity in Healthy Volunteers

Results/Findings:

The data collected from this study shows that oral linaclotide can regulate guanylate cyclase C in the colorectum only when the GI transit time is decreased by the use of a bowel prep. In absence of the bowel prep, the linaclotide peptide drug is broken down before it reaches the colon. The study suggests that a guanylate cycles C-targeted agent that is formulated for release in the proximal should be evaluated in the next study.

Sources: