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Total antioxidant capacity and pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Principal Investigator
Name
Zhong Guo-Chao
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-565
Initial CDAS Request Approval
Jan 8, 2020
Title
Total antioxidant capacity and pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Summary
Pancreatic cancer is the third most common cause of cancer-related death in the United States. Total antioxidant capacity (TAC) is defined as the total amount of moles of oxidants neutralized by one liter of food extracts (1). TAC reflects overall antioxidant potential from foods, beverages, and supplements, with the consideration of the potential synergistic interactions between them (1). Higher TAC has been associated with lower risks of gastric cancer (2), prostate cancer (3), breast cancer (4), and hepatocellular carcinoma (5). However, to our knowledge, no prospective study has investigated the association of TAC with pancreatic cancer incidence and mortality. Clarifying the association of TAC with pancreatic cancer incidence and mortality can aid in tailoring diet-based interventions to reduce the global burden of this disease. Therefore, we used prospective data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial to examine the hypothesis that higher TAC is associated with lower risks of pancreatic cancer incidence and mortality in the US population.
References:
(1) Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: is the Total Antioxidant Capacity the right tool? Redox Rep. 2004; 9(3): 145-152.
(2) Serafini M, Jakszyn P, Lujan-Barroso L, Agudo A, Bas Bueno-de-Mesquita H, van Duijnhoven FJ et al. Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2012; 131(4): E544-554.
(3) Russnes KM, Wilson KM, Epstein MM, Kasperzyk JL, Stampfer MJ, Kenfield SA et al. Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study. Int J Cancer. 2014; 134(5): 1156-1165.
(4) Pantavos A, Ruiter R, Feskens EF, de Keyser CE, Hofman A, Stricker BH et al. Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study. Int J Cancer. 2015; 136(9): 2178-2186.
Aims

(1) Investigating the association of total antioxidant capacity with pancreatic cancer incidence and mortality in the US population.
(2) Performing subgroup analyses to determine the potential effect modifiers.

Collaborators

(1) Jian-Yuan Pu, The Second Affiliated Hospital of Chongqing Medical University
(2) Kang Wang, The First Affiliated Hospital of Chongqing Medical University
(3) Jian-Ping Gong, The Second Affiliated Hospital of Chongqing Medical University

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