A systematic evaluation of dietary and behavioral factors associated with renal cell carcinoma risk and survival
The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial is a randomized, controlled trial enrolling around 155,000 participants between November 1993 and July 2001, providing a comprehensive dataset for RCC incidence and mortality analysis. In addition, diet and behavioral information is also available in questionnaires, such as Baseline Questionnaire (BQ), Dietary Questionnaire (DQX) and Supplemental Questionnaire (SQX). Moreover, the bio-samples collected in PLCO also provide a broad base for serum biomarker and genetic data generation for systematic association study.
1) We plan to systematically evaluate the associations between environmental and behavioral factors (including dietary habits, nutrient supplements, NSAID use, body mass index, physical activity and sleep conditions) and RCC incidence.
2) If serum biomarkers (e.g., Vitamin D) data of RCC cases are available, we plan to include the serum biomarkers into the systematic evaluation of the effects of multiple environmental factors with the survival of RCC patients.
3) If genetic data are available (either targeted array/sequence, genome-wide association study or sequencing data), we plan to investigate the role of genetic variation (as a main effect or interaction with diet and behavioral factors) in relation to RCC incidence or survival.
Shiqi Li, Zhejiang University
Yi Zhu, Zhejiang University
Ping Wang, Zhejiang University
Zhen Liang, Zhejiang University
Sunyi Ye, Zhejiang University
Dan Xia, Zhejiang University